Pregabalin 300mg UK




Buy Pregabalin Online

Pregabalin, also marketed as Azlain and Lyrica, is a medication utilized in the management of epilepsy and various other pain conditions. It falls under the category of anticonvulsants and is effective in controlling and preventing seizures.

FDA Approval and Indications

Pregabalin holds the distinction of being the first antiepileptic agent to receive FDA-approved labeling since 1999. It is prescribed for several purposes, including:

  1. Neuropathic Relief: Particularly after spinal injuries, central neuropathic pain, which stems from conditions like stroke or spinal cord injuries, can be alleviated by pregabalin.
  2. Fibromyalgia Treatment: Pregabalin is used to manage fibromyalgia, a chronic condition characterized by pain, muscle stiffness, fatigue, and sleep difficulties.
  3. Neuropathic Pain: Pregabalin is effective in treating pain caused by damaged nerves, which commonly manifests in the arms, hands, legs, or feet.
  4. Adjunct Treatment for Seizures: In adults and children as young as one month old, pregabalin serves as an adjunct treatment for partial onset seizures.


Mechanism of Action

Pregabalin, a GABA (gamma-aminobutyric acid) analog, acts by slowing down impulses in the brain responsible for seizures. Unlike traditional GABA analogs, pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, modulating the release of excitatory neurotransmitters. This mechanism accounts for its antiseizure and antinociceptive effects.

Comparison with Gabapentin

Pregabalin and gabapentin, both termed “gabapentinoids,” share structural and functional similarities. However, pregabalin boasts more consistent absorption, peak plasma concentrations within an hour, and stronger binding affinity to target receptors compared to gabapentin.

Benefits and Off-Label Uses

Beyond its primary indications, pregabalin offers benefits in managing neuropathic cancer-related pain and serves as an adjunct therapy for migraines. However, these uses are considered off-label and lack FDA approval.

Side Effects and Precautions

Common side effects of pregabalin include dizziness, drowsiness, weight gain, and blurred vision. It’s imperative to avoid alcohol consumption while taking pregabalin, as it can exacerbate central nervous system depression. Additionally, caution is advised in individuals with certain medical conditions, such as angioedema, heart failure, and kidney diseases.

Dosage and Administration

Pregabalin is typically taken 2 to 3 times daily, with or without food. It’s essential to start with a low dose and gradually increase it over time to minimize side effects. Dosage adjustments are necessary for patients with reduced renal function, and clinical monitoring is recommended for geriatric patients.

Duration of Treatment

For epilepsy management, pregabalin may be a lifelong component of the treatment regimen. In cases of nerve pain and anxiety, prolonged treatment may be necessary to achieve optimal symptom relief. Withdrawal from pregabalin should be gradual to prevent withdrawal symptoms.


Pregabalin is a versatile medication with diverse therapeutic applications, ranging from epilepsy management to neuropathic pain relief. Despite its efficacy, careful consideration of dosage, side effects, and potential drug interactions is essential for safe and effective use.


There are no reviews yet.

Be the first to review “Pregabalin 300mg UK”

Your email address will not be published. Required fields are marked *