Co-Codamol 30/500mg


Co-codamol is a painkiller that combines two different types of pain relief: paracetamol and codeine. Paracetamol is classified as an aniline analgesic, and while it is sometimes grouped with NSAIDs, it is not considered an NSAID due to its poor anti-inflammatory properties.



Buy co-codamol 30/500 online

Co-codamol is a painkiller that combines two different classes of pain relief: paracetamol and codeine. Paracetamol is classified under aniline analgesics, but due to its poor anti-inflammatory effect, it is not considered an NSAID despite often being grouped with them. Codeine, an opioid analgesic first isolated in 1832, is used as a central analgesic, sedative, hypnotic, antinociceptive, antiperistaltic agent, and cough suppressant. Co-codamol is indicated for adults and children over 12 years of age and is used to treat headaches, muscular pain, painful menstruation, migraines, and toothache. It can be an alternative to less potent painkillers such as aspirin and ibuprofen. Co-codamol is available under various brand names like Atasol (US/Canada), Solpadeine Plus (UK), Solpadol, and Katakana.


Co-codamol is available in many European Union countries, including Bulgaria, Cyprus, Denmark, Estonia, France, Ireland, Latvia, Lithuania, Malta, Poland, and Romania, as an over-the-counter drug. In the UK, lower doses (8mg codeine/500mg paracetamol) can be bought over-the-counter, but higher doses require a prescription. Countries like Australia, the US, Japan, and the United Arab Emirates have banned the sale of codeine-containing medicines as OTC products. Co-codamol can be purchased online with a prescription in the US, UK, Canada, and India.


Before starting Co-codamol, inform your doctor if you have lung problems, breathing difficulties, head injuries, raised intracranial pressure, adrenal gland problems, seizure conditions, a history of excessive alcohol consumption, are pregnant or breastfeeding, have liver problems, or are under 18 and have had tonsils or adenoids removed due to obstructive sleep apnea.

Drug Interactions

Drug interactions can affect how Co-codamol works and increase side effects. Keep a list of all medications and supplements you use and share it with your doctor. Co-codamol should not be taken with blood thinners like warfarin, antibiotics like chloramphenicol, nausea medications like metoclopramide or domperidone, cholesterol-lowering drugs like cholestyramine, or the oral contraceptive pill. It can increase CNS depression when taken with CNS depressants like anxiolytics, hypnotics, and antipsychotics. Co-codamol can cause drowsiness and dizziness, affecting activities such as driving or operating machinery.

Side Effects

Common side effects include constipation, dizziness, drowsiness, nausea, vomiting, and stomach pain. Prolonged use can lead to addiction and tolerance, and abruptly stopping the medication can cause withdrawal symptoms such as restlessness, agitation, anxiety, difficulty sleeping, and shaking. Overdose symptoms include sweating, pallor, nausea, vomiting, anorexia, and abdominal pain. In severe cases, it can lead to liver damage, CNS depression, respiratory depression, and even death.


Swallow the tablet or capsule with a full glass of water. If you feel nauseous, take Co-codamol with food. The typical dose is one tablet (8mg codeine/500mg paracetamol) every 4 to 6 hours, not exceeding eight tablets in 24 hours. For children aged 12-15, the dose is one tablet every six hours, up to a maximum of four tablets in 24 hours. For those aged 15-18, the dose is one tablet every 4 to 6 hours, up to a maximum of eight tablets in 24 hours. For elderly patients, follow the doctor’s instructions. Treatment duration should not exceed three days without consulting a doctor. If you miss a dose, take it as soon as you remember, but do not double up if it is close to the next dose.

Mechanism of Action

Codeine is a painkiller and cough suppressant similar to morphine and hydrocodone. It is partially metabolized to morphine in the body, mimicking the body’s natural painkillers and blocking pain messages to the brain. Paracetamol works by inhibiting prostaglandin synthesis in the brain, reducing pain signals and controlling body temperature.


Co-codamol provides effective pain relief for mild to moderate pain, with a single dose lasting 4 to 6 hours. It is commonly used postoperatively, especially in children and after neurosurgical procedures, due to its lower risk of sedation and respiratory depression compared to morphine. It is safe to take Co-codamol with ibuprofen and aspirin but should not be taken with other paracetamol-containing medicines to avoid overdose.


Keep Co-codamol out of reach of children and store it in a cool, dry place away from direct heat and light.


Co-codamol combines the benefits of codeine and paracetamol for effective pain relief. However, it is important to use it responsibly and under medical supervision to avoid risks such as addiction, withdrawal symptoms, and overdose. Always follow your doctor’s instructions and report any side effects or concerns promptly.